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Both applications require very specific molecular targeting to attach the PFC nanodroplets to the correct tissues, although some therapeutic delivery could be done via passive targeting [ 82].
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Glass is extremely durable and its non-porous properties mean that both the access of the hybridisation target to attached probes and the washing steps are rapid and highly reproducible.
One interesting way to achieve active targeting is to attach ligands, such as monoclonal antibodies or peptides, to the carrier.
Further still, these targeted treatments will eventually be combined into the same pill, so a Src kinase for example could be joined with a molecule targeting FAK to attach colon cancer cells.
In our study, we then asked whether LIF formulated in PLGA NP targeted to OPC (i) attach to and induce OPC maturation into mature OD in vitro and (ii) improve reparative remyelination in vivo.
A common approach is to attach targeting ligands in order to activate receptor-mediated endocytosis.
From the early 2000s researchers have investigated the use of the so-called click chemistry to attach targeting ligands to the surface of liposomes [ 47, 48, 51].
Microbubbles that are conjugated with targeting ligands attach to endothelial surface receptors that are upregulated in disease, providing high signal-to-noise ratio images of pathological vasculature.
Thus, their great potential lies in the ability to attach specific targeting peptides to plasmids to circumvent such barriers to gene transfer as cell-targeting or nuclear localization, thereby increasing the efficacy of gene therapy.
The hybridize step binds the microRNA targets to the target-specific probes attached to Firefly hydrogel particles.
Aptamers (APTs) are little functional oligonucleotides that are exclusive and incline to attach to target molecules such as drugs, proteins, poisons, and other organic and non-organic molecules.
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