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Earlier research has shown that inhibiting the right DLPFC impairs cognitive control mechanisms, so Bachmann suggests that targeting this region could have increased the automaticity of the participants' responses, making them more likely to tell the truth.
By targeting this region, a potent anti-IAV agent was subsequently created.
However, it has been unsuccessful to generate anti-HIV neutralizing antibodies targeting this region.
Thus, has been demonstrated that antibodies targeting this region could be protective against infection in some cell types and possibly pathological in others [32].
The agents targeting this region may be able to affect the stability or dimerization of HIV-1 RT and subsequently inhibit viral replication.
Phage display with HIV-positive sera primarily results in the identification of immunodominant regions, such as KLIC, because of the abundance of antibodies targeting this region [41].
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Such knowledge will be important in design of drugs to target this region.
Four other miRNAs (miR-93, miR-125a, miR-302d, and miR-373) also targeted this region.
The HIV-1 V3 loop has been previously termed as the "principal neutralizing determinant" of HIV-1, since many HIV-1 neutralizing antibodies from infected individuals target this region of gp120 [19].
We targeted this region because, to our knowledge, it is the only section of the T. cruzi genome so far identified as being transcriptionally silent.
The binding of FoxO6 to this region in vivo was confirmed using CHIP assay, in which we found that FoxO6 specifically targeted this region without binding to the proximal promoter region.
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