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Complement-mediated inflammation has been linked to ischemia reperfusion injury, organ graft rejection and even neurodegeneration, so targeting this process has direct clinical implications.
He proposed to a skeptical scientific community that drugs targeting this process would starve tumors and be another approach to treating solid tumors.
Nevertheless, our data also point to the role of viral factors in targeting this process.
Additionally, the models can aid in the development and optimization of therapies targeting this process [ 16- 19].
In this review, we will discuss the role, molecular mechanism, and regulation of autophagy, while targeting this process as a novel therapeutic modality, in various cancers.
The identification of translation factors suggests that modulation of translation might be a therapeutic approach in poor-prognosis AML, consistent with studies targeting this process in early-phase clinical trials [ 54].
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Researchers based in Dublin, writing in the journal Nature Immunology, say future drugs could target this process.
Many novel therapeutics have been developed which aim to target this process by acting as either angiogenesis inhibitors (e.g. by blocking the action of vascular endothelial growth factor) or as vascular disrupting agents, which target the extracellular matrix [2],[3].
Understanding how iron accumulates in PD may provide opportunities to target this process pharmacologically.
Efficient methods to target this process for large-scale genome manipulations would be beneficial to biotechnology.
In line with the importance of ubiquitination as an immunity-associated PTM, a vast range of plant pathogens target this process with their effectors [ 32].
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