Sentence examples for targeting this phase from inspiring English sources

Since cells can use a variety of potentially redundant mechanisms for their initial aggregation into spheroids (e.g., integrin ECM or cadherin-mediated) [ 140], targeting this phase is likely to require a multifaceted approach.

Some of the difficulty with targeting this phase of the life cycle may be explained by recent work on the proteolytic modification and mobilization of merozoite proteins (Riglar et al, 2011), which showed how the parasite displays the mature active form of the protein on its surface only at the time when its function is required.

The identification of pathways and genes essential to establish and maintain persistence would facilitate the development of drugs which target this phase of infection.

Therapies to target this phase need to be given early in disease when both clinical symptoms and histopathological Mankin scores are low [ 4].

Therefore, neutralizing antibodies to IFN-γ were administered from day 10 to 20 after collagen immunization, targeting this early initiation phase of CIA.

Volasertib (BI 6727), a potent and selective cell cycle kinase inhibitor, induces mitotic arrest and apoptosis by targeting Plk; this phase I study sought to determine its maximum tolerated dose (MTD) in Asian patients with advanced solid tumours.

The programme is targeting this group in a phased approach, beginning with those at very high risk of hospital admission and working downwards to cover the full 20% over a 5-year period.

The identification of translation factors suggests that modulation of translation might be a therapeutic approach in poor-prognosis AML, consistent with studies targeting this process in early-phase clinical trials [ 54].

Thus, resuscitation endpoints targeted during this phase must reflect adequacy of global tissue perfusion.

Therefore, inhibiting MEK prevents cells entering mitosis and consequently the requirement for agents, such as microtubule targeting agents and Aurora B inhibitors, to target cells in this phase of the cell cycle would not be achieved (Wright et al, 1999; Hayne et al, 2000; Yan et al, 2007).

Thus, the target was this phase, not G2.