Sentence examples for targeting this important from inspiring English sources
Conclusions: Despite the fact that the emergence of antimicrobial resistance threatens our future ability to treat many infections, the proportion of the UK infection-research spend targeting this important area is small.
Such data would be useful in designing clinical trials targeting this important subgroup of critically ill children.
By targeting this important adhesion step, we show that the aptamer molecule can inhibit platelet aggregation in PFA-100 and ristocetin-induced platelet aggregation assays.
Further investigation is needed in order to achieve a more complete understanding of the mechanisms and biology of the mitochondria-mediated caspase activation pathway, and for eventual therapeutic application targeting this important pathway.
In addition, we hypothesised that targeting this important heterodimer could induce a therapeutic effect.
It is therefore plausible that mutations targeting this important functional domain may have a pathogenic effect.
In this review, we will summarize the structure and function of K-ras with attention to its role in tumorigenesis and discuss the successes and failures of the various strategies designed to therapeutically target this important oncogene.
MYC is known to be deregulated in a large number of human cancers yet there has been little successful development of drugs that target this important activity [6], [41], [42].
To effectively target this important family of kinases for pharmaceutical intervention, a greater understanding of their activity and regulation is required.
Based on these studies, we provide a proof of concept that targeting CDC25 phosphatases by inhibiting their protein protein interactions with CDK2/Cyclin A substrate represents a novel, viable opportunity to target this important class of enzymes.
The purpose of this review is to focus attention onto the problem, and to consider some of the unexpected confounding variables, describing some of the extant strategies that have begun to achieve progress in the field, in order to stimulate others to target this important problem.
