Achieving high targeting specificity is important for targetable nuclease applications.
This modular nanoparticle design represents a new paradigm in cell-selective siRNA delivery and allows for stoichiometric tuning of dual-targeting components to achieve superior targeting specificity.
Polymeric nanogels protect vaccine antigens from degradation in vivo and, surface-conjugated with antibodies or specific ligands, could increase active targeting specificity.
Nanoparticle-VCAM-1 targeting specificity was confirmed by in vitro binding and competition studies.
The combinatorial approach will enable combination therapy for delivery of multiple drugs and dual ligand targeting to improve targeting specificity.
This system relies on RNA-DNA base-pairing to generate targeting specificity, resulting in efficient and flexible genome-editing reagents.
In this study, we enhanced the cancer targeting specificity of buforin IIb using a tumor-associated enzyme-controlled activation strategy.
Disks had longer half-lives in circulation and higher targeting specificity in mice, whereas spheres were endocytosed more rapidly.
A well-defined, stimuli-responsive tetrapolymer with pH-responsive characteristics and targeting specificity has been synthesized by radical copolymerization of methacrylic acid, N- 2-hydroxypropyl)methacrylamide, methacryloyl glycylglycyl sulfamethoxazole, aN- 2-hydroxypropyl)glycylglyciN- 2-hydroxypropylster.
Using LDLA7 cells partially expressing EGFR-GFP, fluorescence imaging demonstrated the co-internalization of EGFR-GFP and EGF-HPPS, thus validating its targeting specificity.
Numerous studies on QDs have resulted in major advancements in QD surface modification, coating, biocompatibility, sensitivity, multiplexing, targeting specificity, as well as important findings regarding toxicity and applicability.
