We target sole proprietors with one or no employees that operate in traditional, bread-and-butter industries — i.e., beauty salons, cleaning services, caterers — that are not capital-intensive or ultracompetitive.
"The idea of a targeting a sole, legitimate business sector with an additional tax is totally unwarranted and unjust and should be dismissed immediately," Imperial Tobacco said in a statement.
As shown in Table 1, adding a second target region for analysis led to substantially improving HCV genotype 1 subtype identification compared to methods targeting the sole 5'NCR.
In fact, by preferentially targeting the sole tumour cells, DHA should neither induce immune reaction(s) against normal tissues when utilised alone, nor increase that of immunotherapeutic agents (Di Giacomo et al, 2010; Fratta et al, 2011; Garbe et al, 2011) in combination strategies.
The sole targeting of Mcl-1 expression in A172 cells using shRNA technology significantly increased the percentage of cells undergoing apoptosis (Fig 2d) while downregulation of Mcl-1 significantly potentiated the induction of cell death with subsequent R-roscovitine treatment in both A172 and U87 cells (Fig 2d).
The state Attorney General Chris Koster announced Monday that the probe, which had targeted Planned Parenthood's sole Missouri location, did not find any evidence of wrongdoing, and that he won't be filing criminal charges against anyone at the clinic.
Thus, despite its many potential targets, the sole essential role of Rok for myosin II localization is to maintain phosphorylation of the RLC.
This suggests that vascular targeting agents are unlikely to produce a clinical response when used as sole antitumour therapy.
In turn, the sole N terminal sequence was able to specifically drive the targeting of GFP to the vacuole.
We propose that, as sole treatments, targeted drugs like sorafenib are inadequate for control of brain metastases, including metastases to the pituitary from RCC.
