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Jores, T. et al. Characterization of the targeting signal in mitochondrial β-barrel proteins.
A novel targeting signal for proximal clustering of the Kv2.1 K+ channel in hippocampal neurons.
Amino acid sequences of the targeting signal peptides were as follows: cyto, LPPLERLTLD; nuc, LRSRADPKKKRKVDPKKKRKVDPKKKRKVGSTGSR; mito, SVLTPLLLRGLTGSARRLPVPRAKIHSLGDLSVLTPLLLRGLTGSARRLPVPRAKIHSLGD; and perox, SKL.
A third isoform was designed de novo by appending a mitochondrial targeting signal.
The endoplasmic reticulum enzyme DGAT2 is found in mitochondria-associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria.
PEX7 encodes peroxisome targeting signal receptor, while PEX19 is proposed to be essential for the proper localization and stability of peroxisomal membrane proteins.
Lee, C. M., Sedman, J., Neupert, W. & Stuart, R. A. The DNA helicase, Hmi1p, is transported into mitochondria by a C-terminal cleavable targeting signal.
Piguet, V. et al. Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of β-COP in endosomes.
The signals that direct proteins into these organelles are either found at the C-terminus (type 1 peroxisomal targeting signal; PTS1) or N-terminus (type 2 peroxisomal targeting signal; PTS2) of the protein.
AAE15 lacks the predicted plastidial targeting signal.
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The N-terminal end of Bax contains a mitochondrial-targeting signal.
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