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More upstream, initiating apoptotic events, such as mitochondria targeting, result in inevitable cell death [ 138].
However, the off-target alterations that result from Grx1 shRNA targeting result in significant alterations to the intracellular redox buffering capacity of the Grx1 knockdown cells.
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Several studies have indicated that loss of glycosylation can lead to improper folding and targeting, resulting in decreased function and compromised structure [36] [37].
The C829T variant interferes with miR-24 targeting, resulting in DHFR overexpression and MTX resistance [ 73].
EGFR and MET targeting had little effect on cell viability, whereas AXL targeting resulted in ∼50% reduction of mesothelioma viability.
In addition, the bottom row shows that better targeting resulted in less erroneous intensity variations within the myocardial wall.
Knockout of src and tks5 through CRISPR/ Cas9 targeting resulted in a reduction of primordium size and loss of migration.
Deletion of murine c-myc by gene targeting results in embryonic lethality at embryonic day 9-10 [ 23].
Specifically, elimination of CR2/CR1 expression by gene targeting results in a marked decrease in the generation of arthritis following immunization with type II collagen in DBA1/j mice.
Specific CD4 targeting resulted in augmented skin hyperplasia and dermal inflammation in TPA-treated WT mice, but had no effect on EPI−/− skin.
The lack of the CD25 sink and improved tumor targeting resulted in increased systemic exposure of IgG-IL2v compared with IgG-IL2wt in immunocompetent C57BL/6 mice.
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