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This activity is likely monitored by the mitotic checkpoint, and distinct from that of RNAi-mediated heterochromatin formation directly targeting outer centromeric repeats.
In this context, an attractive approach for the development of antibacterial agents is the use of compounds targeting outer membranes of Gram-negative bacteria since they are not expected to readily induce resistance formation.
Bax, a pro-apoptotic protein, induces cell death by targeting outer mitochondrial membrane [ 23].
PCRs targeting outer membrane protein (omp) A and B genes were done by using previously described primers (3 ).
The layer by layer nanoparticle could be divided into three parts in structure: drug-loaded core, siRNA/polycation loaded middle film and tumor targeting outer shell.
They consist of a receptor-binding domain typically targeting outer membrane receptors involved in iron uptake (Baysse et al. 1999; Denayer et al. 2007; Elfarash et al. 2012, 2014), a translocation domain, and a carboxy-terminal toxin domain with nuclease or pore-forming activity.
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We designed qPCR primers targeting the outer membrane protein of B. abortus.
We present an approach via immunization targeting an outer membrane protein FomA of Fusobacterium nucleatum (F. nucleatum), a central bridging organism in the architecture of oral biofilms.
PEG6K-b-PCL19K polymersomes covalently labelled with these peptides demonstrated effective targeting to outer hair cells in a rat cochlear explant study.
We provide evidence that flagellar-deficient mutants harbor inadequate amounts of LPS required to resist membrane permeabilization by SP-A and cellular lysis by detergent targeting bacterial outer membranes.
Selected genes were further screened for the presence of transmembrane domains using TMHMM [ 47, 48] and signal peptides targeting the outer membrane using HECTAR [ 49].
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