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To date, targeting of recognized driver genes delivered suboptimal results in breast cancer [ 35].
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21 22 These schemes have provided drugs, but generally not diagnostic support, and poor targeting of antimalarials is recognized as a major risk to these efforts.
Cyber-Physical Intrusion Detection Systems are a novel type of IDS that are targeted to recognize physical manipulations of a control system.
This fundamental observation is critical to the development of MHC anchor modified peptides, because vaccination using these reagents could lead to the targeting of T cells that can recognize the modified peptide, but not the natural peptide present on the surface of tumors.
Nevertheless, it is recognized that specific targeting of GSC antigens during T cell induction may yield distinct findings.
This pattern of multiple independent LSEs is common among eukaryotic genes with immunity- or defense-related functions: the multiplicity of diverged paralogs provides the means for maximizing the diversity of recognized targets [ 79- 81].
The notion of regional drug targeting should be recognized as an essential extension of the rational design of sequence-specific drugs.
Initial support for this came with the repression and/or down-regulation of a number of recognized STAT3α target genes when STAT3β was overexpressed [ 10, 48].
The presence of tissue-specific targeting signals not recognized in Xenopus oocytes may lead to protein degradation [ 9].
The monoclonal antibody F8 was chosen as fusion partner of proven tumor targeting performance, which recognizes the alternatively-spliced EDA domain of fibronectin, a marker of angiogenesis.
We next evaluated the frequency of "favourable epitopes" targeted among all recognized HIV-1-specific CD8+ T-cell epitopes in both cohorts.
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