Sentence examples for targeting of components from inspiring English sources

Data have generally been interpreted based on the assumption that DAT-Cre will be active in all DA neurons and similar assumptions are common in neighbouring research fields where DAT-Cre mice are used to target other gene expression in DA neurons [e.g. the selective targeting of components of the glutamatergic machinery; reviewed in Rodriguez Parkitna and Engblom (2012)].

The reasons for such conspicuous genotype phenotype discrepancies among tissues and species are elusive, but emerging evidence support that the subcellular assembly, sorting and targeting of components of pre-ciliary complexes mediated by RPGRIP1 present remarkable cell type-dependent structural and functional plasticity.

Such thrombi have both platelet and fibrin components [ 12], requiring targeting of both components to ensure effective prevention of thrombus formation.

Vaccine efficacy is strongly enhanced by antibody-mediated targeting of vaccine components to dendritic cells (DCs), which are professional antigen presenting cells.

Luciferase reporter assays were used to confirm miR-9 targeting of these components.

Thus, therapeutic targeting of individual components of the ERK pathway has attracted much attention for developing antitumor agents.

However, the recruitment or targeting of complex components to chromatin does not exclusively depend on this self-enforcing loop.

New therapeutic strategies, involving the combination of known targeted therapies with conventional cytotoxic drugs and the targeting of other components involved in angiogenesis, need to be developed.

Future MR perfusion studies may lead to identification of objective hemodynamic correlates of painful DN enabling the targeting of specific components of the pain matrix pharmacologically, hopefully resulting in the development of more effective and better tolerated drugs.

To identify genes affected by direct targeting of a component of the transcriptional complex implicated in WNT regulation, we used siRNAs to knockdown TCF7L2 in PANC1 cells.

The direct targeting of signaling component gene promoters by RB family members may provide one means for a molecular linkage of these conserved pathways.