Sentence examples for targeting of cells from inspiring English sources

Cellular immunotherapy relies on several highly variable patient-specific parameters, such as (i) cell number before and after expansion, (ii) targeting of cells to tumors, (iii) cell survival and function after infusion, and (iv) on- and off-target adverse events.

Novel trends in cell separation are also highlighted, including the use of novel ligands (e.g. aptamers) for affinity targeting of cells, the application of "tag-less" methods to avoid cell labeling, and the use of microfluidics and other microscale devices.

This surface chemistry provides diverse ways for functionalizing through conjugation of nucleic acids (DNA, RNA, and synthetic nucleic acids such as locked nucleic acids [LNAs], peptide nucleic acids [PNAs] etc)., (poly)peptides or cellular ligands; e.g. thiocitic acid polyethylene glycol folate gold conjugates developed for targeting of cells with folate receptors [74].

Like several other cancers, it is becoming increasingly evident that neuroblastoma is a stem cell disease; thus, therapeutic targeting of cells that cause relapse is vital to improve patient outcome.

Given its central role in the targeting of cells towards apoptosis upon genotoxic stress, the regulation of HIPK2 has been the subject to intense investigation in the last years.

In clinical settings the inactivation of host cell function [101] and the antiphagocytic properties [102] of ExoS should aid in the infectious process, but its limited cytotoxicity, combined with its inefficient targeting of cells of lymphoid origin, may favour the production of more cytotoxic factors, such as ExoU and exotoxin A [103], at certain sites of P. aeruginosa infection.

The targeting of cell-surface membrane protein also has the potential benefit of distancing the labeling agent from potentially sensitive sites in the cell.

Conversion of progenitor fate restriction signals to constitutive recombinase expression enables viral targeting of cell types based on their lineage and birth time.

We speculate that this cost-effective technology could one day bolster or even supplant the use of monoclonal antibodies in the targeting of cell surface cancer antigens.

For noninvasive imaging of CSCs as well as CSC-specific therapies, the targeting of cell surface proteins using antibodies or other receptor ligands is particularly relevant [18].

Our observations have potential implications for future therapeutic strategies based on targeting of cell cycle deregulation such as via cyclin-dependent kinase (CDK) inhibition.