Sentence examples for targeting of a single from inspiring English sources

Indeed, cancer cells overcome easily the targeting of a single genetic aberration through development of resistance.

This issue limits the targeting of a single EPH receptor for antitumor therapy.

Preclinical mouse models have employed targeting of a single tumour antigen with some success.

The target sequences for HIF-1, HIF-2 and scramble control RNAi were selected from the relevant ORF region of the human cDNA sequence according to the manufacturer's recommendations (Cruachem Limited, Glasgow, UK) and submitted to a Basic Local Alignment Search Tool search (National Centre for Biotechnology Information database) to ensure targeting of a single gene.

18 These findings have brought into question some of the original thinking in terms of the design of antiangiogenesis therapy, in as much as it is no longer clear that selective targeting of a single factor and/or isoform will necessarily achieve the desired result of angiogenesis inhibition in the tumor microenvironment.

The target sequence for PDK-1 was selected from the ORF region of the human PDK-1 cDNA sequence using Dharmacon si DESIGN Center guidelines and criteria developed by Dharmacon scientists and described by Reynolds et al (2004) and submitted to a Basic Local Alignment Search Tool search (National Centre for Biotechnology Information database) to ensure targeting of a single gene.

Furthermore, systems biology means that intracellular signalling networks have many redundant and compensatory pathways, making targeting of any single component potentially a futile approach.

This strategy however permits the targeting of only a single tumor antigen by the engineered T lymphocytes with the risk of tumor variants selection.

Traditionally drugs have been designed with the aim of targeting a single biological entity, usually a protein (the so-called "on-target"), with high selectivity to avoid any unwanted effects arising from mis-targeting other biological targets ("off-targets").

Highly specific in vivo targeting of an emerging neoplasm through a single molecular recognition mechanism has not generally been successful.

Thus, an emerging goal in cancer treatment is not just the targeting of single proteins, but engaging an entire network and its related networks to halt or reverse the disease [12].