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The superiority of enhanced passive targeting resulted from small size, plus the active targeting ability of targeting molecules, will doubly promote the tumor-targeted imaging.
When conjugated with CSC-specific antibody or targeting molecules, AuNPs have a potential application in CSC-targeting therapy.
For example, the dual-targeting for prostatic cancer was realized via the conjugation of two targeting molecules on PAMAM [24].
Polymer strands on the outside of the nanocarrier bear targeting molecules that are recognized only by tumor blood-vessel cells.
These targeting molecules bind to proteins found in the lining of the blood vessels that surround adipose tissue.
Active targeting molecules displayed better cell selectivity but were shadowed by the poor tumor penetration effect.
The targeting molecules recognize proteins on the outside of cancer cells and so help bring the nanopharmaceutical to its desired location.
To do so, say the researchers, they will need to develop highly specific targeting molecules for each disease to ensure that healthy blood cells are spared.
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Antimicrobial peptides are universal host defense membrane-targeting molecules in a variety of life forms.
The PAEEP segment containing a large number of amino groups can be modified with tumor-targeting molecules, such as lactoferrin (Lf), an effective targeting ligand for gliomas.
Folic acids (FAs) were introduced on the micelle surface as tumor-targeting molecules.
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