Sentence examples for targeting leads from inspiring English sources

Deletion of either one by gene targeting leads to the loss of mature osteoblasts and lack of calcified bones [11], [12].

At both dosing frequencies of inhaled formulations of RIF, increased macrophage targeting leads to decreased antibiotic exposure in granulomas and actually hinders sterilization of bacteria (Table 1).

As Noxa specifically targets Mcl-1 this is additional evidence that specifically Mcl-1 inactivation along with Bcl-XL targeting leads to cell death.

In-depth analysis of specificity, capacity, affinity and avidity of all the peptide candidates is underway on matrix, sonicated samples and GAG-coated plates to select targeting leads for evaluation in preclinical studies.

Similarly, in non-small cell lung cancer (NSCLC), and in pancreatic cancer, KRAS appears to be one of the main drivers, and its targeting leads to a drop in Betti number from 50 to 37 (26 % reduction) for NSCL, and a drop from 38 to 29 (24 % reduction) for pancreatic cancer (Table  1).

One of the possible explanations for the presently observed supra-additive anti-tumour activity may lie in an optimal 'vertical blockade' of VEGF pathway not obtained by either agent alone bearing in mind that EGFR targeting leads to inhibition of VEGF tumour secretion (Byers and Heymach, 2007).

In early tests, the targeting led to a 500 to 600 percent increase in eCPMs (the money that advertisers effectively paid for each 1,000 impressions).

But inflation targeting, led by the Federal Reserve, resulted in higher unemployment rates than necessary and slower growth in wages for most workers.

The cellular depletion of PRMT1 by small interfering RNA targeting led to increased HIF transcriptional activity.

These results suggest that public health reforms targeting lead exposure were largely successful.

In all cases, the shRNA targeting led to approximately 50percentt reduction in gene expression levels.