Sentence examples for targeting integration from inspiring English sources

During normal lentivirus infection, the host cell encoded transcriptional coactivator lens epithelium derived growth factor/p75 (LEDGF/p75) binds lentiviral integrase (IN), thereby targeting integration to active transcription units and increasing the efficiency of infection.

Recently, a multi-scale design approach was developed for carbon-hydrogen-oxygen symbiosis networks (CHOSYNs) with focus on the targeting, integration, and retrofitting of EIPs involving a set of existing facilities.

Studies of both cell models and both lentiviruses provided strong evidence for the role of LEDGF/p75 in promoting efficient infection and targeting integration in transcription units.

Because more than half of the favoring of transcription units was eliminated by the stronger depletion of LEDGF/p75, we can conclude that the LEDGF/p75-dependent pathway is the predominant pathway for targeting integration to transcription units.

The resulting plasmid was linearized with NsiI, targeting integration in the intergenic region of PFR2.

Briefly, ViDOS was a cluster, randomized controlled trial in 40 LTC homes (21 control; 19 intervention) that examined the feasibility and effectiveness of a knowledge translation intervention targeting integration of best practices for osteoporosis and fracture prevention.

Plasmids were digested with BstEII to target integration to LEU2, and the number of copies of MPS3 integrated was determined by Southern blotting.

HEases have been designed to target disease-associated genes, such as XPC [ 7] and RAG1 [ 8], to induce targeted integration in cell lines [ 9, 10], and for targeted mutagenesis in crop [ 11].

Suzuki, K. et al. In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration.

Yao, X. et al. Homology-mediated end joining-based targeted integration using CRISPR/Cas9.

Cristea, S. et al. In vivo cleavage of transgene donors promotes nuclease-mediated targeted integration.