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Both peptides were stable in vivo and showed excellent and specific tumor targeting (Figure 5) in an AR42J rat pancreatic tumor model.
Second, molecules can be attached to the surface of these nanoparticles to target specific cells or tissues (active targeting) (Figure 1) [17].
Mice lacking one allele of Tnnt2, designated Tnnt2+/−, were generated by gene targeting (Figure 1).
NPC cells expressing dominant negative ARF6, ARF6(T27N), exhibited no change in Ctx targeting (Figure S4).
We found no relationship between the population frequency of a 10-mer and CTL targeting (Figure 6).
Compared with the free molecule, labeled polymeric micelles were detected in greater extent in CNV sites confirming passive targeting (Figure 7F, n = 3).
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Differences between the electrostatics on the surface of the nematode proteins themselves and H. sapiens reflect opportunities for specific species targeting (Figures 4, S4, S5).
For example, the degree of abnormality within the brain subdivisions varied depending on which RP gene was targeted (Figure 3B).
Of 372 G418-resistant ES cell clones, 4 clones were identified as being correctly targeted (Figure 1B).
In light of these results, we examined macroH2A1 localization in mouse embryonic stem cells (mESCs) in which both alleles of macroH2A1 are genetically targeted (Figure S1).
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