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In the experiment, the targeting efficacy of the dual-targeted liposomes was compared to single-targeted liposomes to demonstrate the synergistic effect.
Predicting microRNA targeting efficacy in Drosophila.
Despite drug formulation improving circulation times and targeting, efficacy is stymied by inadequate penetration into and retention within target tissues.
When modified on the surface of nanocarriers, those peptide ligands would readily degrade and the targeting efficacy is significantly attenuated.
The study was designed to enhance the cancer targeting efficacy of radiolabeled resveratrol using nano-based technology.
As our result proved, using oligoclonal nanobodies as targeting moiety enhance targeting efficacy in comparison with monoclonal VHH.
Here, we evaluate the targeting efficacy of FA by incubating ZIF-8/5-FU@FA-CHI-5-FAM and ZIF-8/5-FU@CHI-5-FAM with FA-positive MGC-803 cells and FA-negative HASMC cells for 2 h.
Indeed, considering alternative 3′ UTR isoform usage improved prediction of targeting efficacy significantly beyond the improvements observed when considering constitutive isoform usage.
We developed new hyaluronan-based nanoparticles targeting CD44 receptors of two different sizes and compared their lung cancer cells targeting efficacy in vitro and in vivo.
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We evaluated the expression levels of hCAR, EGFR, and FGFR1 on a range of cell lines, as well as on primary patient-derived EOC cells, in order to select suitable model cell lines for evaluating adenovirus re-targeting efficacy.
Owing to the fast kinetics of radiopeptide localization to target sites upon entry in the bloodstream, only rapidly occurring degradation events—as those related to NEP are relevant for tumor-targeting efficacy.
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