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On the one side, radiosensitive effect were totally shown via 99mTc-Annexin V SPECT for apoptosis; on the other side, targeting effect enhanced radiosensitive effect effectively.
Experience with monoclonal antibodies against nontumour-specific antigens such as CD20 and EGFR (Tobinai, 2002; Goldberg, 2005) suggests that the enhanced expression of TfR on tumour cells and the targeting effect of Tf Hp may provide an effective therapeutic window.
This explains why a more significant targeting effect was seen in these metastases by targeted delivery [ 23].
Following encapsulation of PTX, FA-PLP-131I was the most effective at suppressing B16F10 cell proliferation without cytotoxicity, attributed to the FA targeting effect.
Thus, the NPs possessed a good passive targeting effect.
Protein corona formation even stealth active targeting effect of AuNPs.
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It is believed that a drug with durable, lung-targeted activity and low systemic exposure would have a theoretical advantage over current therapies with improved therapeutic index, allowing for better pulmonary-targeting effect and minimized systemic effects.
The in vivo tumor-targeting effect of LXY30 was evaluated in an orthotopic mouse model by optical imaging.
Ultrasound treatment of 1 MHz produced an increase in the drug release from the systems, illustrating the drug-targeting effect of the combination of AALs and ultrasound.
The in vivo tumoral accumulation measurement showed that the tumor-targeting effect of RELs was 5-fold higher than that of non-targeting liposomes.
The self-targeting effect and in vitro cell viability of the MTX-PEG-CPT NRs on HeLa cells were demonstrated by comparative cellular uptake and MTT assay of the PEG-CPT NRs.
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