Sentence examples for targeting death from inspiring English sources
It was found to enhance proliferation and resistance in lung cancer cells by targeting death receptor 5 (DR5) although through a non-exosome associated pathway (Yuan et al. 2014).
Targeting death receptor activation-mediated cell death is quickly becoming one of the most promising strategies for anti-cancer therapy [3], [4].
Targeting death receptors, such as Fas, is a promising anticancer strategy by which apoptotic cell death can be induced.
Another mechanism to take advantage of matrix mechanical properties therapeutically is in targeting death of cells via alterations in matrix rigidity.
Various approaches have been described for targeting death receptor ligands to the tumors including construction of TRAIL fusion proteins using antibody fragments directed against overexpressed tumor antigens [ 11].
Antibodies targeting death receptor 5 (DR5), a cell surface apoptosis-inducing receptor up-regulated in various types of cancer and found on HCT116 cells, were then conjugated onto the particles.
report their studies of an MCSPxDR5 bispecific, tetravalent antibody that can simultaneously target death receptor 5 (DR5, TRAIL-R2) and melanoma-associated chondroitin sulfate proteoglycan (MCSP).
Female gamers like Anita Sarkeesian and Brianna Wu receive targeted death threats on a regular basis.
Activated caspase-8 cleaves and activates the effector caspase-3, and activated caspase-3 cleaves target "death proteins" such as poly (ADP-ribose) polymerase (PARP) leading to apoptosis.
An alternative therapeutic option is to target death receptors such as Fas.
Early clinical studies with monoclonal antibodies targeting programmed death protein 1, programmed death-ligand 1 and cytotoxic T-lymphocyte-associated antigen 4 have shown anti-tumor efficacy.
