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These data suggest that both enzymatic and transcriptional TOP2A targeting contributes to bDMC cytotoxic activity.
The authors hypothesize that perturbations of Kirrel3-dependent synapse targeting contributes to intellectual disability, as mutations of Kirrel3 have been associated with neurodevelopment disorders.
Inhibition of TrxR1 may explain why APR-246 also has activity against tumor cells lacking mutant p53, and raises the possibility that TrxR1 targeting contributes to the apoptosis-inducing effect of APR-246 in mutant p53-expressing tumor cells.
TOP2A knockdown leads to about sixfold increase of SubG1 events, and bDMC treatment for 24 h is not able to further augment apoptosis, suggesting that direct TOP2A targeting contributes to bDMC pro-apoptotic activity.
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That final flurry of absentees, along with other forms of voter targeting, contributed to a surprising GOP victory that cut through the heart of the Democrats' broader 2006 election strategy.
These facility level targets contributed to the district and national annual targets [ 24, 25].
Our results suggest Sirt1 targets contributing to physiological resveratrol effects and the revealed substrate sequence dependent outcome indicates that Sirt1 inhibition should also be involved.
These internal NIHR CRN targets contributed to the public High Level Objectives that include a median approval time across all trial sites of 40 days.
We observed significantly increased levels of replication of mCMV in BMDMs following treatment of the cells with a number siRNAs (data not shown) however the mechanisms by which the genes targeted contribute to the antiviral phenotype are largely unknown.
If a target contributes to good clinical outcomes, it stays; if it does not, it goes". Harman said: "The prime minister has not answered.
Assess whether target contributes to the vision of the entire chaebol; analyze and integrate different opinions of managers those supporting the deal brought very positive NPV while those opposing it brought very negative valuation indicators.
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