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Thus the basic rationale of the design and development of nanomedicines in cancer therapy is failing making it necessary to stop claiming efficacy gains via the EPR effect, while tumor targeting cannot be proved in the clinic.
With current tools, however, accurate targeting cannot be achieved.
However, impaired axonal targeting cannot explain deficits in CA1 hippocampal neurons; these cells maintain mitochondria in axons, even without Drp1.
If perfect targeting cannot be achieved (transductional targeting), further transcriptional confinement of the transgene may be achieved by using cardiac-specific promotors.
However, because KLΔ9 shedding was severely reduced (more than 90%), the modest observed decrease in plasma membrane targeting cannot explain the impaired shedding for this mutant.
The augmented protective capacity of CsA against OGD-induced necrosis obtained by mitochondrial targeting cannot be explained by increased inhibition of mitochondrial CyP-D, as CsA was tested at concentrations (1 μM) sufficient to inhibit CyP-D completely (in B50 cells, 0.8 μM total CsA completely reversed the PT activation by CyP-D overexpression; Figure 5C).
Similar(54)
The 44 MPs who wrote to Corbyn to complain that his supporters were disproportionately targeting women cannot be ignored.
These particles with low uptake and no targeting ability cannot be considered as a suitable candidate for hyperthermia.
This data suggests that conceptual change strategies, despite directly targeting misconceptions, cannot overcome students' prior conceptions of evolutionary concepts.
Renewable energy targets cannot deliver this result.
Targets cannot be imposed from outside.
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