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Barzilai now believes the answer is to design a drug trial that, rather than targeting aging per se, tries instead to delay the onset of "comorbidities": the chronic diseases whose incidence rises sharply as people get older.
These findings have implications for treating specific diseases, including neurodegeneration and cancer, as well as targeting aging in general.
The process for bringing new prescription agents targeting aging to market has been described in detail by Kirkland [ 4], and the steps, time lines and costs involved are extensive.
The preclinical-to-clinical research programs created by the National Cancer Institute in the U.S. to facilitate translation of novel cancer therapies has been advanced as another possible model to fast-track promising treatments targeting aging [ 4].
Accumulating scientific evidence from studies conducted in various organisms and species suggests that targeting aging will not just postpone chronic diseases but also prevent multiple age-associated metabolic alterations while extending healthy lifespan.
Dr. Nir Barzilai, director of the Institute for Aging Research at the Albert Einstein College of Medicine, has designed an anti-aging study called "Targeting Aging with Metformin" (TAME).
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If we could target aging, that would have an impact on diseases.
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Barzilai, N., Crandall, J. P., Kritchevsky, S. B. & Espeland, M. A. Metformin as a tool to target aging.
"I'm looking for therapies that target aging damage and slow or reverse it," she says.
"This highly targeted and super effective serum made up of 22 active botanicals targets aging, acne and problematic skin.
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