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Both tmk and dut were assessed to be bacteriostatic genes [50] and since these genes belong to the same pyrimidine biosynthesis pathway, have no human homologs and are essential for the survival of Mtb, can be targeted together to produce a synergistic bactericidal effect.
Since we have also shown that TIEG1 and Runx2 proteins interact, one could speculate that complexes consisting of these two proteins could be rapidly targeted, together or separately, for proteasomal degradation.
One is synthetic lethality where redundant functions must be targeted together to cause cell death [ 30].
We identified the vesicles on which RIN2 was targeted together with R-Ras 38V as GFP-Rab5A-positive early endosomes.
The other is induced-essential synthetic lethality where compensatory functions must be targeted together to cause cell death [ 30].
Although details of RNAi assays will need to be optimized for each gene targeted, together, these results will prove useful for future functional studies of M. sexta chemosensory genes.
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Moreover, folic acid (FA -modified OCMCS-FA -modifiedmbined receptOCMCS-Fe3O4 targetiNPsand magneticombineding together [24].
A week before my daughter left, we went to Target together.
In cells, this protein displays preferential adhesion site targeting together with a low cytoplasmic pool and induces a rise in adhesion site density.
In addition, targeting together mTOR and EGFR might cause a more profound effect on tumour growth control compared with a single agent (Hynes and Lane, 2005).
This work demonstrates the potential of CXCR4 targeting together with MMP triggers and cycloaddition chemistry for enabling the production of efficient and more sensitive cancer MRI in vivo.
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