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In 1975, working with Köhler, who was a postdoctoral fellow at Cambridge, Milstein developed one of the most powerful tools of molecular biology: monoclonal antibody production, a technique that allows researchers to construct cells that produce great quantities of identical (monoclonal) antibodies, all targeted to recognize the same antigen.
Likewise, the analysis of proteins, their post-translational modifications in normal and pathological conditions, coupled with the development of highly specific antibodies targeted to recognize different forms and states of proteins, including antibodies that work inside living cells (Attreed et al., 2012), will play pivotal roles in deciphering the molecular mechanisms of lens development.
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Therefore, these studies collectively provide robust evidence that PBD-phosphopeptide binding is essential for PLK-1 targeting to recognize the substrate and also regulate the PLK-1.
In this nanosysytem: TiO2 Yb,Ho,F was used as upconversion materials and applied in vivo for the first time; β-CD acted as a "protective umbrella" to load separated ICG and avoid the low phototherapy efficiency because of its aggregation; HA was the capping agent of β-CD to prevent ICG unexpected leaking and a target to recognize CD44 receptor.
Nevertheless, it remains very poorly understood how the enzymes responsible for initiating these functional chromatin states are targeted to and recognize defined regions of the genome.
DNA hypermethylation in inflamed tissues is also strongly targeted to genes recognized by the Polycomb complex [ 38].
Results from both high-grade GBMs were similar and supported the hypothesis that QDs targeted to EGFR can specifically recognize glioma cells ex vivo.
The importance of prevention interventions targeted to couples is increasingly recognized [3], [20].
In addition, neisserial Omp85 proteins are integrated into the OMM with the help of the SAM complex, but neisserial PorB proteins, although targeted to mitochondria, are not recognized by the SAM complex and do not form OMM complexes.
However, it is not clear how protein aggregates are recognized and targeted to the autophagosomes.
NK cells do not need previous exposure to their target cells to recognize, bind to, and destroy these targets (e.g., cancer and virus-infected cells) (Vivier et al. 2008).
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