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Intestinal epithelial cells (IEC) somatically targeted to express the ATG16L1 T300A variant show protection against invasion by Salmonella.
Cholinergic vagal preganglionic neurons of the DVMN characteristically express the transcriptional factor Phox2 and can be targeted to express the gene of interest using viral vectors with Phox2 activated promoter (PRSx8).
Skp2, when targeted to express in the T-lymphoid lineage, along with activated N-Ras, promotes N-Ras-induced T-cell lymphoma formation with shorter latency, higher penetrance, and significantly decreased survival, indicating a strong N-Ras-cooperative effect.
In organotypic brainstem slices, C1 neurones were targeted to express a fluorescent protein DsRed2 under the control of PRS×8 promoter while astrocytes were transduced to express ChR2(H134R).
We hypothesize that compensation is likely to develop over time to restore high arterial blood pressure by either recruitment of other mechanisms driving the activity of RVLM presympathetic neurons or by enhanced activity of presympathetic neurons residing in other regions of the central nervous system, not targeted to express TMPAP (eg, paraventricular nucleus).
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This study targets to express the piglet odorant-binding protein (plOBP) and compare the engineered product to the corresponding native protein forms, i.e. plOBP and adult porcine OBP (pOBP).
We have reached out to Target to express our concern over this contribution.
RESULTS: In order to develop a more effective, etiological therapy for EE, we have used AAV-mediated gene targeting to express the human ETHE1 protein in vivo.
Billie Holiday was an obvious early target to express our angst for us.
Even more strikingly HP1a gets targeted to highly expressed genes such as hsp70 thereby regulating its expression after heat shock [14].
The expression of an eGFP-L10a ribosomal transgene was targeted to cells expressing 10-formyltetrahydrofolate dehydrogenase (ALDH1L1), with the goal of tagging polysomes and immunoaffinity purify mRNAs [ 13].
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