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Could the immune response be specifically targeted to aid patient recovery?
Our work supports a role for CCL3L1 copy number in immune reconstitution following antiretroviral therapy in HIV, and suggests that the MIP1α -CCR5 axis might be targeted to aid immune reconstitution.
Finally, the long-term follow up will enable us to assess long-term effects of sodium restriction, whilst also observing barriers and enablers to dietary adherence that may be targeted to aid sodium restriction.
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Understanding this would allow randomised controlled trials of treatment in the paediatric population, as well as support further functional imaging and pharmacologcical research against novel therapeutic targets, to aid better treatment of this common and disabling condition.
It is a circular mechanism containing structures and targets to aid docking.
There is a pressing need to identify novel antifungal drug targets to aid in the therapy of life-threatening mycoses and overcome increasing drug resistance.
citri pathotypes may provide new targets to aid in the prevention of bacterial diseases and possibly inform new strategies to treat and manage citrus canker outbreaks.
It is important to find new therapeutic targets to aid in the design and discovery of novel drugs as well as implementing genetic screening to identify individuals at risk so they can be targeted for prophylactic treatment.
We envisage a mechanism for this action in which an sRNA activates the catalytic domain of RNase E, whilst other components of the degradosome assembly together with RNA binding domains in the C-terminal half of RNase E might interact with the mRNA target to aid presentation of the target site to the catalytic groove of RNase E [55].
The targeted allele also contains a 43-bp fragment corresponding to human OCT4 gene sequence [described in Hockemeyer et al. [ 10]] that can serve as a zinc finger nuclease target to aid in insertion of additional sequences for future needs, but the component is not tested yet.
During prophase, SAC proteins are targeted to kinetochores to aid in proper kinetochore microtubule interactions (Supplementary Figure 5).
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