10.7554/eLife.06885.006 Figure 3. miR-9 inhibited astrogliogenesis via targeting three components of Jak-Stat pathway.
The phenotype was importantly reproduced when targeting three different components of the canonical autophagy core machinery.
To explore this latter possibility, we pooled siRNA oligonucleotides targeting two Ska components simultaneously, in the hope that this would achieve a more complete depletion of the Ska complex than any 'single' knock-down.
Furthermore, XRCC1 was overexpressed in BRCAX patients; consequently, we suggest to test the effectiveness of inhibitors targeting two different BER components in preclinical studies.
Recently, the anti-PM-Scl autoantibodies have been shown to target six human exosome components that make up an RNA-processing complex, namely hRrp4p, hRrp40p, hRrp41p, hRrp42p, hRrp46p and hCs14p.
In this paper, we propose compiler scheduling algorithms targeting two previously ignored power-hungry components in clustered VLIW architectures, viz., instruction decoder and register file.
Hexavalent vaccines targeting six diseases are the largest multi-component combination vaccines currently available.
Taken together, we found that targeting each of the three components of DISC precludes the induction of apoptosis by the alkyl-lysophospholipid analogue edelfosine.
The intervention targeted clinicians with five components: clinician education, local champions, academic detailing, clinician feedback of quality data, and system supports.
ADCs consist of three components, the targeting antibody, the cytotoxic payload, and the linker that couples those two components together (Fig. 1).
