Sentence examples for targeted the expression of from inspiring English sources

The LMNA G608G transgenic mice targeted the expression of the Hutchinson-Gilford progeria syndrome (HGPS) mutation in keratin-5-expressing tissue led to a typical phenotype of HGPS [16].

To investigate the role of EZH2 in the mammary gland, we targeted the expression of EZH2 to mammary epithelial cells using the mouse mammary tumor virus long terminal repeat.

Here, we targeted the expression of a bundling-competent KRT5/KRT8 chimeric cDNA (KRT8bc), or bundling-deficient wildtype KRT8 as a control, to the epidermal basal layer of Krt5 null mice to assess the functional importance of keratin IF self-organization in vivo.

To further demonstrate the role of VEGFR-2 as a target of these VEGFR-TKIs in the synergistic cytotoxicity observed in combination with lovastatin in MM cells, we specifically targeted the expression of VEGFR-2 employing short inhibitory RNA sequences (siRNAs).

Functionally, miR-133a can suppress tumor cell invasion and migration and targeted the expression of FSCN1.

We have targeted the expression of the light chain of tetanus toxin to the GF, to block chemical transmission, in shak-B flies.

The chicken genome has miRNAs that can potentially target the expression of the genes expressed from the segment 2 of H5N1 virus.

Additionally, immunofluorescence targeting the expression of CD11b, which is a molecular indicator of microglial activation.

Delivery of siRNA that targets the expression of class II transactivator (CIITA), a positive regulator for the transcription of MHC class II molecules, produces a brief period of refractoriness to interferon (IFN -γ-mediated IFN -γ-mediatedC class IFN -γ-mediated

This present study is the first to use RNA interference to target the expression of VGLUT1 in a specific brain region in vivo as a novel means of manipulating synaptic glutamate release.

However, viral miRNAs actively target the expression of cellular genes involved in relevant functions such as cell proliferation, DNA repair or RNA regulation.