The experiments on this issue are under way using tumor targeting techniques such as functionalization of PSi with specific antibodies.
Our results open up the use of intrabodies in the field of serpinopathies, with unique advantages over existing gene-targeted techniques such as silencing/interfering RNA or RNA aptamers (called "intramers" when intracellularly expressed) (43, 44).
Focal, anatomically targeted recording techniques, such as intracranial recordings, offer insight into how single neurons and small neuronal populations are entrained into network behavior but the clinical constraints on these recordings and their limited sampling space should make it challenging to detect replay in humans.
In the context of drug action, we analyse the strengths and limitations of classical mutagenesis and gene targeting techniques, as well as alternative approaches such as chemical mutagenesis, gene trap, recombineering, transposon-mediated mutagenesis, chromosomal engineering, viral transgenesis and RNA interference.
The AGA says objects and buildings can also be protected using "target-hardening" techniques, such as lighting, gates fences and anti-climb devices.
The Ciona community is also on the cusp of harnessing targeted loss-of-function techniques such as ZFNs, TALENs, and RNAi.
If a pulse-Doppler framework is advocated, then stationary clutter such as those described may be mitigated using simple moving target indication (MTI) techniques such as the delay line canceler [19].
Crucially, the difference we observed could be due to the use of real-time PCR, which is much more efficient and requires fewer targets than hybridization techniques (such as Northern blot), detecting low amounts of RNA initially present in each sampling time.
These identified proteins could be targeted with antibodies using established techniques such as hybridoma or phage display [ 17].
To precisely place the electrode in the brain, surgeons rely on three-dimensional target coordinates obtained using techniques such as magnetic resonance imaging or computerized axial tomography.
For the large-scale identification of transcription factor target sites, several laboratory techniques, such as chromatin immunoprecipitation (ChIP) and DNA adenine methyltransferase identification (DamID), have been devised (Orian 2006; Pokholok et al. 2002; Ren et al. 2000; van Steensel et al. 2001; Wyrick et al. 2001).
