Sentence examples for targeted sense from inspiring English sources

Second, with respect to hairpin transgene-induced silencing, the loop portion of the hairpin construct we used is retained in the mature transcript and has sequence identical to that of the targeted sense transgene.

The highly abundant secondary siRNAs in the dcl4 mutant included 24-nt as well as 22-nt siRNAs, showing that both DCL3 and DCL2 produce secondary siRNAs from the targeted sense transgene when DCL4 is defective.

Generation of miRNAs targeting sense Alu sequences may thus have been a relevant early event in the expansion of the Alu family in primates.

In this model, homology sites of Alu sequences helped duplicating a gene cassette encoding miRNAs, which in turn can target sense Alu sequences and thus alter the fate of free Alu elements.

ASOs targeting sense transcripts reduce sense RNA foci and ameliorate transcriptome changes and toxicity in C9FTD/ALS-derived cells [ 8▪▪, 17▪▪, 22 ▪].

Indeed, in relation to the relative selective vulnerability of motor neurons in C9ORF72-mediated pathology in vivo, targeting the antisense foci may be even more important than targeting sense foci.

ASOs targeting antisense transcripts may also be required as it was proposed that antisense RNA-mediated mechanisms were responsible for the proportion of transcriptional changes that remain dysregulated after treatment of patient cells with ASOs targeting sense repeats [ 17▪▪].

Reads from both libraries were specifically mapped to predicted cassava miRNA targets' sense or antisense strand to assess the extent to which transitivity or miRNA silencing signal amplification occurred in cassava.

Such genomic organization of host genes and antisense miRNAs might have a regulatory function to interfere with miRNA transcription, or might affect the host gene to influence mRNA splicing or to target sense mRNA.

No protein sequestration into antisense RNA foci has yet been identified, but this could be important as ASOs targeting sense RNA did not reverse all transcriptome changes in C9FTD/ALS-derived fibroblasts [ 17▪▪].

Along with the search for new therapeutic agents, advanced formulation and fabrication of drug carriers are required for better targeting, sensing, and responding to environmental stimuli as well as maximizing treatment efficiency.