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We conclude that it does not have a targeted role.
Although widely expressed, the increased cerebellar expression of CNTN1 suggested a more targeted role than a housekeeping function.
Esa1, the HAT component of NuA4, which mainly acetylates the H4 tail, bound to promoters upon derepression, however in contrast to SAGA, its recruitment was largely activator independent, suggesting it may play a global, rather than targeted role (Fig. 1D).
Further studies in murine and human tissues have demonstrated a more targeted role for ALDH2 that explains nitroglycerin tolerance,.
However, in contrast to Csf1 op / Csf1 op mice, ductal elongation was not defective, indicating a more targeted role of eosinophils on the branching pattern.
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However, this intervention needs to be in an unequivocal combat role, not just in an intelligence, surveillance and targeting role".
All of the results suggested that the covalent chemistry, preferring over physical adsorption, could be advantageous to preserve the targeting role of MTX.
Besides, it turned out that the delivery system could be efficiently endocytosed by tumor cells, which attributed to its admirable biocompatibility and the targeting role of folate.
This result indicated that the chemical linkage between MTX and MTX-PEG-CPT NRs was cleavaged by the combination of enzyme and pH to release the active MTX drug, "turn off" the targeting role of MTX while "turn on" the anticancer role of MTX.
Studies of a subset of CpGs that coincide with methylation-sensitive restriction sites in the promoter of Oct-4 have suggested a targeting role for the H3K9 methyltransferase G9a in recruiting Dnmts to Oct-4 [31].
The VHS domain has a membrane targeting role in vesicular trafficking in eukaryotic cells [ 20].
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