Sentence examples for targeted replication from inspiring English sources

We examined a study's power to replicate a main effect for a SNP with a true epistatic effect in a highly targeted replication study for a single SNP association.

Targeted replication studies and functional analysis of nominated genes are highly desirable, as some of the loci identified via GWAS are likely to be false positive signals.

Analyses of these datasets were followed by targeted replication analyses in two independent efforts [29], [30].

This ignored multiple-hypothesis testing issues and represented the situation where there existed a targeted replication hypothesis.

The targeted replication of the CD association of ATG16L1, IL23R and DLG5 also serves to illustrate the highly conservative criteria employed in our study, which may have resulted in an under-appreciation of most initial association findings.

Towards development of targeted replication inhibitors, we have focused on Mcm2-7 (maintenanceome maintenance protein 2 7), a highly conserved helicase and key regulatory component of eukaryotic DNA replication.

Because of the various properties of each viral vector, the definition of their application range depends on factors such as packaging capacity, host range, cell- or tissue-specific targeting, replication competency, genome integration and duration of transgene expression.

Similarly, taxol class drugs indirectly target replication by stabilizing tubulin.

On the basis of these findings, the tempting possibility of targeting replication proteins and their regulators as part of antitumour therapies that interfere with cancer cell proliferation certainly merits consideration.

Unique among the replication initiatives thus far, the pipeline project corpus includes the data from not only the replications but also all of the original studies targeted for replication.

SNPs that reach genome-wide significance (p < 5 × 10−8 after correction for multiple-testing, 0.05/1,000,000 independent tests among common variants in the human genome) are specifically targeted for replication and further functional experiments [ 33].