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A recent study showed that enzymatically modified antibodies can be used to generate highly targeted, potent immune responses.
42 Nevertheless, given that even weak selective pressure against p7 can drive HCV to escape, evidenced by the selection of both Leu20Phe 34 and potentially other polymorphisms, 35 the prospect of employing targeted, potent molecules becomes highly attractive.
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These peptides are of low molecular weight, synthetically versatile and inexpensive to produce, suggesting that they can be used as drug targeting, potent, stable and bioavailable agents.
It is quite surprising to see the number of microRNAs that can co-target potent tumour suppressors and oncogenes.
Our data demonstrate the potential risk associated with clinical application of broadly acting covalent epigenetic modifiers, and highlight the value of combination therapies that include agents specifically targeting potent pro-metastatic genes.
Current developments target potent drugs with a predictable mode of action, easy mode of administration and minimal requirements for blood control.
Rather than stressing differences that enable increasingly targeted and potent messaging, this type of segmentation aims to find populations of customers who share a notion of what constitutes excellent service.
The membrane-proximal external region (MPER) of the human immunodeficiency virus, type 1 (HIV-1) envelope glycoprotein subunit gp41 is targeted by potent broadly neutralizing antibodies 2F5, 4E10, and 10E8.
The use of a targeted and potent repressor domain increases the efficiency of transcriptional repression of cancer-causing genes.
It acts through irreversible CYP17 inhibition, but is more targeted and potent than the older generation, non-specific CYP inhibitor, ketoconazole.
Design of effective antibody drug conjugates for cancer therapy requires selection of an appropriate target, a monoclonal antibody against the target, potent cytotoxic effector molecules, and conjugation of the monoclonal antibody to cytotoxic agents.
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CEO of Professional Science Editing for Scientists @ prosciediting.com