Sentence examples for targeted pathways from inspiring English sources
Although it is not possible to evaluate the biological importance of the 6 genes that were identified without functional genetic manipulation (e.g., knock-in), our resampling analysis revealed that these targeted pathways were not statistically significant.
Based on this approach, neither 3 genes in the interaction term (p = 0.27), nor 3 genes in the main effect of drug (p = 0.54) were found to be significant, inspiring little confidence in PIO's ability to manipulate these targeted pathways.
Although these analyses are far from perfect in terms of predictive ability, they remain the only tools available for predicting miRNA targets, and the output of these analyses is useful for predicting hypothetical connections between miRNAs, targeted pathways, and biological functions.
Thus, the distilled cardiac and vascular sub-network rationally targeted pathways for enhancement of cardiovasculogenesis. Network architecture deconvolution predicted the necessary combination of signaling axes to stimulate prioritized hubs, and thus activate in a targeted manner the preferential signaling highways for cardiogenic specification.
Other deregulated miR-145 targeted pathways included axonal guidance signaling and the ERK/MAPK pathways.
These factors may affect the mechanisms by which the targeted pathways are regulated.
drug companies are now increasingly teaming up to clinically test targeted pathway inhibitor combinations.
They highlight new avenues for drug development that would target pathways of the mesothelium's mesenchymal transition.
Puri, V. et al. Clathrin-dependent and-independent internalization of plasma membrane sphingolipids initiates two Golgi targeting pathways.
And by targeting pathways unique to the cancer cells, the researchers hope to reduce undesired toxicity effects.
The authors suggest that conservation organizations target pathways that are most feasible given their own expertise, while supporting other organizations in mitigating related pathways.
