Sentence examples for targeted pathway from inspiring English sources

Regulating the Hippo pathway thus represents a potential therapeutic approach to treat cancer, which however requires deep understanding of the targeted pathway.

Growth inhibition of compound 2 toward KB cells resulted in cytotoxicity and G1/G2-phase accumulation, and was partially protected by excess thymidine and adenosine, but was completely reversed in the combination of thymidine and adenosine, indicating both thymidylate and de novo purine nucleotide synthesis as the targeted pathway.

What emerges instead is the importance of sets of altered regions whose individual members hit different parts of a targeted pathway.

drug companies are now increasingly teaming up to clinically test targeted pathway inhibitor combinations.

A number of studies have reported drug targeted pathway that was the effective therapeutic approach in treating cancer [ 10– 15].

76 Another emerging mechanism of acquired resistance is amplification or reactivation of the same targeted pathway genes.

Using a targeted, pathway-level analysis, we identified 26 gene sets differentially expressed when comparing sufficient versus deficient vitamin D status.

Other deregulated miR-145 targeted pathways included axonal guidance signaling and the ERK/MAPK pathways.

Apoptosis was predicted to be one of the most likely targeted pathways of QSYQ [ 37].

These factors may affect the mechanisms by which the targeted pathways are regulated.

The five most specifically targeted pathways were shown in Figure 3D.