Sentence examples for targeted pathology from inspiring English sources

The main disadvantage of modulating naturally occurring multi-regulatory mechanisms is the off-target effects that could be potentially caused by targeting mRNAs or proteins that are unrelated to the targeted pathology.

In addition, duration of ONO-1301 release can be adjusted by modifying the molecular weight of PLGA, the lactic/glycolic acids ratio or the particle size to achieve optimum effects, depending upon the targeted pathology or drug delivery mode [ 25].

This might indicate that in more chronic conditions of mental health issues the improvement of QoL could be worth considering in the therapeutic process independent of targeting pathology.

New approaches to targeting pathology offer hope of new analgesic options and, for the first time, structure modification may be possible by treating a noncartilage target, the subchondral bone.

The clusters are activated within the target pathology by diagnostic US, undergo an ensuing liquid-to-gas phase shift and transiently deposit 20 30 μm large bubbles in the microvasculature, occluding blood flow for ∼5 10 min.

We only pooled data from studies involving the exact same index test and target pathology.

This section discusses suitable target pathology and delivery method of this reagent, and studies necessary for the first-in-human study.

This is of particular importance in the heterogeneous MCI population, since inclusion of a significant proportion of individuals without amyloid pathology introduces noise into the clinical trial, and may expose individuals without the target pathology to needless risk.

Once the target pathology and the delivery mode of the ONO-1301SR treatment were decided, dose-optimisation study ideally using a large animal model is necessary to launch the clinical study.

Since several prostagrandin agonists are the standard treatment of primary and secondary PAH in the clinical practice [ 81, 82], an ideal target pathology of ONO-1301 and/or ONO-1301SR treatment might be PAH or associated lung diseases.

Although positive effects of ONO-1301SR treatment were proven on a variety of cardiac pathologies, such as acute MI, idiopathic dilated cardiomyopathy, ischaemic cardiomyopathy, cardiac allograft disease post-transplantation or fulminant myocarditis, it is a key of success of this treatment to optimise delivery method of ONO-1301 for each target pathology in clinical study.