Sentence examples for targeted mutation of the from inspiring English sources
Importantly, targeted mutation of the Siglec G gene dramatically expanded the B1a B cell lineages postnatally, by increasing NFκB activation.
For example, targeted mutation of the transferrin receptor-2 gene was shown to induce haemochromatosis in mice [ 11].
Furthermore, targeted mutation of the NCoR protein that prevents HDAC3 binding is sufficient to disrupt hepatic circadian rhythm, further indicating the shared epigenetic underpinnings of the circadian and metabolic gene networks 41 (Fig 2).
Li, E., Bestor, T. H. & Jaenisch, R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.
Li, E., Bestor, T.H. & Jaenisch, R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.
Targeted mutation of the mouse HE6 counterpart resulted in male infertility, further emphasizing its role as a candidate target for male contraception.
Furthermore, mice carrying targeted mutations of the gene, Dnmt3L, demonstrated the necessity of this DNA methyltransferase-like gene to the establishment of genomic imprints in the female germline.
The indispensability of CpG methylation to the maintenance of genomic imprints in eutherians was first demonstrated by the loss of imprinting in mice carrying targeted mutations of the maintenance DNA methyltransferase gene, Dnmt1 [ 9].
Moreover, targeting mutation of the ER-I2PP2A/SET-GFP had no inhibitory effect on its binding activity to ceramide compared to WT-I2PP2A in vitro (Supporting Information Fig S4B).
Moreover, the hybrid motif mediates transcriptional activity since targeted mutation of either the hybrid sequence specifically (Hyb-) or the C/EBP motif generally (C/EBP-) lowered luciferase activity.
Since the targeted mutation of PML increases the yield of infectious viral particles [26], it is postulated that the disruption of PML NBs and the re-localization of PML protein represents a viral strategy to evade a cellular resistance mechanism.
