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A more complete appreciation of the maize circadian clock will reveal where the circadian system impacts maize growth and development, as well as highlight novel approaches for optimization of crop production through targeted modification of the circadian system.
However, an increasing demand for tissue-specific Cre-expressing rat lines can be anticipated in the near future, as the first successful gene targeting in rat embryonic stem cells was recently published [ 51] and several other tools for the targeted modification of the rat genome, such as zinc finger nucleases [ 11, 12] or transcription activator-like effectors [ 52], are emerging.
A special apparatus allowing for the targeted modification of the physicochemical characteristics of dispersive systems via a self-organised liquid flow (Bénard-Marangoni or Railegh-Bénard instability) was constructed.
Moderate correlations between seven continuous traits, such as methane production or microbial protein production, and the presence and abundance of 17 OTUs were found, indicating scope for targeted modification of the microbiome to improve the energetic efficiency of rumen microbial synthesis and reduce the greenhouse gas footprint of ruminants.
Another future goal is the targeted modification of the murine stroma to achieve a more human-like appearance without compromising the normal function of the gland.
Model organism studies allow the targeted modification of the genome and can help with the identification of genetic causes for human diseases.
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Homologous recombination is commonly used to target modification of the yeast genome.
MNP provided the main advantages of both types of targeting: as with passive targeting, modification of the nanoparticle surface is not necessary, and like active targeting, they can be directed to the site of interest [2].
MNs share the main advantages of both types of targeting; as with passive targeting, modification of the nanoparticle surface is not necessary, and like active targeting, they can be directed to the area of interest.
"What are the moral implications of genome editing?" is the question that has been posed by the Nuffield Council on Bioethics regarding the new CRISPR-Cas9 mediated germ-line genome editing technique, which allows targeted modification of DNA sequences at the level of the germ-line, i.e. gametes (eggs and sperm).
Recently, new technologies that use customized nucleases to facilitate targeted modification of genomic DNA have energized the field of genome engineering (Gaj et al. 2013).
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