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The model transformations can be either unidirectional (only source model can be modified; targeted model is regenerated automatically) or bidirectional (target model is also modifiable, requiring the source model to be modified in a synchronized way) in nature.
Subsequently, the conformational energy required to change the peptide backbone conformation (ΔEbbone) from the global energy minimum conformation to the identified bioactive conformation was calculated for 20 hPEPtargetedted model prodrugs with known Ki values.
From the targeted model, 65 (Additional file 2: Table S1.2) out of 243 genes (Additional file 2: Table S1.1), 85 (Additional file 2: Table S2.2) out of 243 proteins (Additional file 2: Table S2.1) and 29 (Additional file 2: Table S3.2) out of 61 identified metabolites (Additional file 2: Table S3.1) were significantly affected in the transgenics.
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In addition, if a Swerling I target model is used, the target amplitude is constant within a CPI.
This paper introduces a new targeting model and procedures to analyse existing design options ahead of design.
A simple Gaussian target model has also been employed in all examples, as in [2, 18], which is also known colloquially in the signal processing literature as a Swerling I target model [2].
The following targeting model could be put forward for AtGCSI.
We developed a TALEN-mediated gene targeting model in D. pulex.
Graphical report mainly targets model diagnostics with a series of plots for different assumption testing.
"These behavioral targeting models seem like the holy grail.
Advertising companies fashion their behavioral targeting models differently, but generally the practice involves linking demographic information and Web site visits.
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