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The second method targeted measurements based on the expected decrease in forecasted water level error variance at a validation time and location, quickly calculated for various sets of measurements by an ensemble transform Kalman filter.
Bio-monitoring analysis following chemical exposure is commonly obtained via chemical-oriented targeted measurements.
Nevertheless, techniques for carrying out targeted measurements in human serum have been developed.
Moreover, MS targeted measurements have also proved reproducible in assays across many different proteomics laboratories [ 66].
Nevertheless, a small number of studies report targeted measurements of amino acids and other compounds in hemolymph using hybrid liquid chromatography (LC -MS and capiLC -MSelectrophoresis-landr inducapillaryelectrophoresis-laseredures.
Data-independent MS/MS acquisition has shown promise for improving the consistency of peptide identifications, as well as for increasing protein sequence coverage in complex samples and creating broad untargeted measurements that are more similar to possible targeted measurements [ 25- 27].
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Once these time points had been chosen, we extracted the outcome data from the time nearest to these targeted measurement times.
In the subsequent validation step, targeted measurement of the elucidated potential biomarkers is applied to a large sample set to study the diagnostic power (sensitivity, specificity, robustness, etc).
Targeting measurements based on the decrease in forecast error variance was shown to be more efficient than a systematic sampling method.
The term "available targets" hereafter refers to target measurements that were not filtered out by a given platform.
This new, technological medium brought the promise of better ad targeting, measurement and pricing models.
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