Exact(3)
Hemminki A, Tomlinson I, Markie D, Järvinen H, Sistonen P, Björkqvist AM et al. Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis.
Using a combination of targeted linkage analysis and PCR-sequencing that allows analyzing up to 10 genetic loci associated with SNHL.
The Mss1 locus had been detected by a targeted linkage analysis with chromosome 10 simple sequence length polymorphisms after the discovery that ENU-induced MPNST of (BDIV × BDIX) F1 rats had been shown previously to display losses of heterozygosity on this chromosome usually losing the BDIV resistance allele.
Similar(57)
Specific target linkage and mode of binding were established using co-crystallization and protein mass spectrometry studies.
This method distributes unit masses simulating revolute or prismatic joints depending on the number of assigned degrees of freedom, analyzes the kinetics of unit masses coupled with constraint forces, and designs the existence of these constraint forces to minimize the root-mean-square error of the output paths of synthesized linkages and a target linkage using a genetic algorithm.
Ataxin-3 has a ubiquitin chain-modifying activity, and especially targets Lys63 linkages in mixed linkage ubiquitin chains (16).
In addition, we used a literature-based network analysis of all MEDLINE records (title and abstract) to group the target-linkage genes from our microarray data using a Natural Language Processing (NLP) regimen for gene and protein names.
It indicated that all the necessary enzymes were probably produced to act on the target linkages and release hydroxycinnamic acids.
Figure 3 (adopted from [ 27]) shows what genetic variants that may be detected with three primary strategies (genome-wide linkage, targeted sequencing and genome-wide association).
By understanding the influence and effects of emergent inter-organizational linkages on organizational perceptions, health promotion professionals are better equipped to develop network-level intervention strategies that target the linkages that exist or should exist among organizations.
Thus, if used in conjunction with cleverly engineered cell lines targeting receptor cytoskeletal linkages, probing the kinetics of receptor cytoskeletal unbinding with ultrasensitve force techniques can provide unique physical insight into the interactions involved in the chemical functions of a molecular adhesion complex.
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