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It may be too costly or impractical to replicate the targeted index completely.
The targeted index (ratio of NCO to OH equivalents times 100) was 105.
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Targeting indices were calculated from the observed data and plotted against the administered antibody dose, indicating that the targeting index is much lower at higher antibody doses.
Predicted targeting index at a 2000-μg 2000-μg 89Zr-J591 was 0.80 comparedose the ofserved targeting index for that dose of 0.78 ± 0.10 (mean ± standard error).
The linear model here predicts a constant, dose-independent targeting index.
The maximum targeting index for the experimental Ab levels was 3.4 at the lowest dose of 60 μg.
We also sought to predict the optimal targeting index (ratio of integrated-tumor-to-integrated-plasma activity concentrations) for radioimmunotherapy.
The antigenic sites are saturated at high antibody doses, and further increases in the administered dose do not produce corresponding increases in targeting index.
We found that our non-linear compartment model performed well in predicting the targeting index at higher doses and was far more appropriate than a linear compartment model.
The targeting index was defined as the ratio of the time-integrated activity concentration in the tumor to the time-integrated activity concentration in plasma.
A significant 1.61-times increase in half-life was observed for GBC and the drug targeting index (DTI) value was calculated to be 9.91.
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