Sentence examples for targeted in mouse from inspiring English sources

We conclude that both Tet1 and Tet2 loci can be efficiently targeted in mouse embryos using electroporation to deliver the CRISPR/Cas9 reagents.

A powerful tool for postgenomic analysis of mammalian gene function is gene targeting in mouse ES cells.

Thomas, K. R. & Capecchi, M. R. Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells.

The use of engineered nucleases in one-cell stage mouse embryos is emerging as an efficient alternative to conventional gene targeting in mouse embryonic stem (ES) cells.

To investigate the effects of in vivo genomic DNA double-strand breaks on the efficiency and mechanisms of gene targeting in mouse embryonic stem cells, we have used a series of insertion and replacement vectors carrying two, one, or no genomic sites for the rare-cutting endonuclease I-SceI.

Here we generated Muc16 mutant mice using gene targeting in mouse embryonic stem (ES) cells.

Gene targeting in mouse R1 ES cells [69] was performed by the Stanford Transgenic Facility.

Gene targeting in mouse embryonic stem cells was performed as already described [35].

Gene targeting in mouse ES cells (TC1) from 129S6/SvEvTac (129/SvEv) was carried out using the procedures described previously [27], [51].

These vectors were used for gene targeting in mouse ES cells, and the resulting conditional alleles were transmitted through the germ line.

Professor Capecchi presented the importance of gene targeting in mouse models of various human diseases, including cancer and neuropsychiatric disorders.