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Targeted expression of a therapeutic agent is a major bottleneck in designing a drug delivery system.
As constitutive expression of OsIRT1 may disturb metal homeostasis in rice, they suggested that targeted expression of OsIRT1 using specific promoters might solve this problem.
This rational and simple design will allow the use of this construct for the targeted expression of other therapeutic nucleic acid molecules as well.
Advances in light microscopy techniques and the use of targeted expression of neuronal and molecular markers in transgenic animals allow more elaborate circuit mapping.
In an earlier investigation, we have demonstrated that the targeted expression of a cysteine protease in tapetal cell layer resulted in complete male sterility in tobacco transgenic plants.
Class-specific inhibition of Gq-mediated signaling was produced in the hearts of transgenic mice by targeted expression of a carboxyl-terminal peptide of the α subunit Gαq.
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Further, RAGE depletion specifically targeted to cortical/hippocampal neurons or neuron-targeted expression of a signal transduction-deficient mutant of RAGE abolished AGE-induced p38 phosphorylation.
Furthermore, strategies focusing on increased accessibility of cellulose-degrading enzymes to their substrate have been developed, and rely on cell wall-targeted expression of glycoside hydrolases, cellulose binding modules (CBMs) or other cell wall modifying proteins.
Glia-targeted expression of the transgene that causes neuronal migration defect was achieved without the defect.
In this study we used the CAG promoter for kidney-targeted expression of the DT-A gene.
In conclusion, the mitochondrially-targeted expression of orf220 gene was capable of inducing male sterility in transgenic stem mustard.
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