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The fact that the TMS stimulation used in the study had such a targeted effect on memory networks makes Voss optimistic that the technology could counteract memory loss.
Our results suggest Rag2 may have a targeted effect on aphids, potentially associated with the production of specific allelochemicals.
Thus we hypothesized that the DNMT inhibitors AZA and DAC could have a targeted effect on AML1/ETO-positive leukemic cells, and be active at lower doses.
One possibility is that there are genes that have a targeted effect on development of focal brain regions, such as prefrontal cortex, which are important for a wide range of verbal and nonverbal cognitive skills.
Given the complexity of AD, a clear distinction is lacking as to whether the expression of DNA-PK subunits may have been transcriptionally impaired in AD brains because of a hitherto unknown upstream event that is too generic to have a specifically targeted effect on DNA-PK.
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We also examined the targeted effects of ganetespib on critical mediators of cell cycle division at the protein level.
This indicates that FGFR induction in response to gefitinib is not due to off-target effects of the drug, but is related to targeted effects on functional EGFR signaling.
Changes in diet could have targeted effects on muscles and zones directly related to chewing.
More recently, however, it has been appreciated that they also modulate specific cellular signalling pathways through targeted effects on susceptible molecules, especially when generated in lower amounts an action that is termed "redox signalling" [ 25, 56].
These results demonstrate the high cellular uptake of FA-PLP-131I, likely due to the FA-mediated targeting effect on B16F10 cells.
The conclusion from these results was, therefore, not to proceed clinically with CPEC as a single agent for solid tumours, but to investigate the exploitation of its targeting effect on CTPs.
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