We expect the spatial targeting considerations to be similar, because the density of the characterized APCs resident in the skin is comparable (e.g. Langerhans cell density is 542±17 mm−2 in mouse ear skin (for the strain tested in this study) [22]; and 730±60 mm−2 in human upper arm skin [32]).
Identifying pre-diagnosis factors that are predictive of dying within a short time interval following a cancer diagnosis should help us understand whether certain individuals (or groups of individuals) should be targeted for consideration of prompt PCP referral upon diagnosis.
Conservation among strains is a basic requirement for target consideration.
When deciding on engagement targets, consideration should be given to the types of results that UNICEF would consider as reflective of an effective engagement.
(1) Diseases: Variations in disease targets preclude consideration of product development for specific pharmacodynamic or clinical outcomes in this limited monograph.
Those include defining the imminence of the specific threat and the operational seniority of the target, considerations outside of the overview of the US courts.
Distance-to-target considerations, e.g., number of indicators close (to be defined) to the targets.
Where possible, targets were identified for the selected indicators for distance-to-target considerations comparing current indicator values with targets.
All stages of a drug discovery program will be covered, from target considerations to lead optimization, strategies to tune reactivity and computational methods.
The assessment was based on distance-to-target considerations, i.e. to which degree the set, proposed or desirable target will be met within the framework of the existing energy policy.
