Intervention 2 targeted anticipated consequences and required GPs to respond to a "persuasive communication" containing a series of pictures representing the consequences of managing URTI with and without antibiotics.
His team needs to set new targets, consequences and inducements beyond those already in place.
This scenario would imply that alteration of hair form, mammary structure and any possible effect on tooth morphology, are 'off-target' consequences of pleiotropic EDAR action.
To further confirm that the observed apoptosis in our experiments was caused by specific downregulation of MMP-2 and not due to any off-target consequences, we supplemented cells with recombinant human MMP-2 (rhMMP-2).
A vital assumption in siRNA-mediated gene silencing is that knockdown of the target gene is exclusive, and without off-target consequences.
More complete studies are needed to determine the role of MRJ-L in macrophages, as well as more directed therapeutic targeting to specific cells to avoid potentially devastating off-target consequences.
It can be envisaged how Hfq acts as a catalyst for such recognition in vivo, but the question naturally arises how sRNAs generally achieve precision, accuracy, and speed in producing their effects and avoid undesired off-target consequences.
If you recommend military action, you've got to think, What forces, what targets, what consequences?
Ultimately, we won't see an end to our "war on terrorism" without dealing with the underlying causes, and not just targeting the consequences of growing terrorism.
Undoubtedly, studies targeting functional consequences of BMPR2 obesity risk variants on BMPR2 transcription are inevitable to clarify whether genetic variants can explain variation in BMPR2 mRNA expression.
[As these constructs overlap considerably in their description and their operationalisation, this intervention is referred to from here on as targeting "anticipated consequences".
