Sentence examples for targeted conditional from inspiring English sources

To provide incentives to potential contributors and researchers to submit their targeted conditional driver strains to CreZOO, our aim is to continue acting as the European specialized database providing a high standard repository, exclusively for Cre and other targeted conditional driver strains.

We used a new strategy which facilitates the identification of correctly targeted conditional alleles by culturing ES cells in replicate plates after Cre-mediated deletion of a loxP-flanked resistance cassette.

We await more specific tools to manipulate brain glucokinase – perhaps targeted conditional transgenic murine models – to examine in a more definitive way whether brain glucokinase plays a broader role in energy metabolism.

The RAGE knockout mouse was designed at Wyeth Research (generated at Lexicon Genetics Incorporated, The Woodlands, TX, USA) as a gene targeted conditional knockout in 129SvEv-Brd mice in which Cre recombinase excises exons 2, 3, and 4. The resulting deletion results in a frame shift and truncation of the RAGE protein, and protein is not produced.

Targeted conditional alleles contain a minimum of three lox sites.

Targeted conditional somatic mutagenesis defines an entirely new scientific field, already widely in use for the production of mutant mouse ES cell lines, each of which carries an altered or 'floxed' allele of a single gene.

To better understand the function of EGFR signaling in articular cartilage in vivo, in this study we have developed a murine model in which activation of EGFR signaling is targeted to the developing and adult limbs, including the joints and articular cartilage, via limb mesoderm-targeted conditional loss of Mig-6, an endogenous intracellular inhibitor of EGFR signaling [ 37].

To target conditional loss of p53 to the mammary epithelial compartment, we crossed Trp53 F/F conditional mutant mice (Liu et al., 2007) with our Wcre mice.

Therefore, it may seem that selection can only target conditional strategies at two levels: the genetic switchpoint that determines which alternative phenotype will be expressed in each environmental condition [ 19]; and the physiological cascade that is involved in phenotypic expression per se (i.e., the downstream mechanisms, [ 63]).

These mutants were created by targeting conditional Nrp1-null mutants (Nrp1 fl/fl) (Gu et al., 2003) with two well-characterised, tissue-specific transgenes, the Tie2-Cre line, which is active in endothelial, but not neural cells (Kisanuki et al., 2001), and the Nes-Cre line, which expresses CRE under the control of the promoter for nestin (Petersen et al., 2002).

In some cases, these adaptive psychological mechanisms will involve specifically targeted or conditional altruistic motivations, involving capacities for discrimination to focus benefits on kin or on reciprocators.